Abstract
Novel 2-imidazoles have been identified as potent partial agonists of the alpha(1A) adrenergic receptor, with good selectivity over the alpha(1B), alpha(1D) and alpha(2A) receptor sub-types. Sulfonamide 23 possessed attractive drug-like properties with respect to physicochemical and ADME properties and wide ligand selectivity.
MeSH terms
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Adrenergic alpha-1 Receptor Agonists*
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Adrenergic alpha-2 Receptor Agonists
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Adrenergic alpha-Agonists / chemical synthesis
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Adrenergic alpha-Agonists / therapeutic use*
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Humans
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Imidazoles / chemical synthesis
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Imidazoles / therapeutic use*
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Models, Chemical
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Receptors, Adrenergic, alpha-1
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Receptors, Adrenergic, alpha-2
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Structure-Activity Relationship
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Sulfonamides / chemistry
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Sulfonamides / pharmacology
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Urinary Incontinence / drug therapy*
Substances
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ADRA1A protein, human
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ADRA1B protein, human
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ADRA1D protein, human
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ADRA2A protein, human
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Adrenergic alpha-1 Receptor Agonists
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Adrenergic alpha-2 Receptor Agonists
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Adrenergic alpha-Agonists
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Imidazoles
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Receptors, Adrenergic, alpha-1
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Receptors, Adrenergic, alpha-2
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Sulfonamides